The Complete Guide to Profhilo — How It Works and What to Expect

Last updated: 5 March 2026

What Is Profhilo and Why Is It So Popular?

Profhilo has rapidly become one of the most sought-after injectable treatments in aesthetic medicine, and for good reason. Unlike traditional dermal fillers that add volume to specific areas, Profhilo is a bio-remodelling treatment that works by stimulating your skin’s own collagen and elastin production from within. The result is a natural improvement in skin quality, hydration, and firmness that looks entirely authentic.

At Axiom Aesthetics, our practitioners have witnessed the transformative effects of Profhilo on patients of all ages and skin types. This comprehensive guide will walk you through everything you need to know about this innovative treatment, from the science behind it to what you can expect during and after your sessions.

The Science Behind Profhilo

Profhilo contains one of the highest concentrations of hyaluronic acid (HA) available in any injectable product, at 64mg per 2ml syringe. What makes it unique is the patented NAHYCO technology, which combines both high and low molecular weight hyaluronic acid without the use of chemical cross-linking agents.

How NAHYCO Technology Works

The high molecular weight HA provides a mechanical lifting and hydrating effect, whilst the low molecular weight HA stimulates the production of collagen, elastin, and adipocytes. This dual-action approach means Profhilo does not just temporarily improve skin appearance but genuinely remodels the tissue from within.

When injected into the skin, Profhilo spreads evenly across the tissue due to its unique thermally bonded structure. This means fewer injection points are needed compared to traditional skin boosters or fillers, reducing discomfort and the risk of complications.

The Biological Response

Research published in peer-reviewed dermatology journals has demonstrated that Profhilo stimulates four different types of collagen (types I, III, IV, and VII) as well as elastin. This is significant because different collagen types serve different functions in skin health:

• Type I collagen provides structural support and tensile strength
• Type III collagen supports skin elasticity and is abundant in youthful skin
• Type IV collagen forms the basement membrane between the epidermis and dermis
• Type VII collagen anchors the epidermis to the dermis, preventing sagging

Who Is Profhilo Suitable For?

One of the greatest advantages of Profhilo is its versatility. It is suitable for a wide range of patients and concerns, making it an excellent entry point for those new to aesthetic treatments as well as a valuable addition for experienced patients.

Ideal Candidates

Patients aged 30 and above who are beginning to notice early signs of skin laxity, fine lines, and reduced hydration often see remarkable results. However, Profhilo is equally effective for patients in their 50s, 60s, and beyond who want to improve skin quality without the more dramatic results of surgical procedures. Common concerns that Profhilo addresses include loss of skin firmness and elasticity, crepey or dehydrated skin texture, fine lines on the face neck and hands, overall dull or tired-looking complexion, and skin laxity on the neck and decolletage.

Treatment Areas

While the face is the most popular treatment area, Profhilo is also highly effective on the neck, hands, inner arms, and decolletage. These areas often show signs of ageing earlier than the face and can be more challenging to treat with traditional approaches.

The Treatment Process: What to Expect

Your Initial Consultation

Every Profhilo treatment at Axiom Aesthetics begins with a thorough consultation. During this appointment, your practitioner will assess your skin quality, discuss your concerns and goals, review your medical history, and determine whether Profhilo is the most appropriate treatment for you.

The BAP Technique

Profhilo is typically administered using the Bio Aesthetic Points (BAP) technique. This involves five injection points on each side of the face, strategically placed to allow the product to disperse evenly across the tissue. The injection process itself takes approximately 15 to 20 minutes. Most patients describe the sensation as a mild stinging that subsides quickly.

The Two-Session Protocol

Profhilo works on a two-session protocol, with treatments spaced four weeks apart. This timing is essential because the first session begins the bio-remodelling process, whilst the second session builds upon and amplifies the initial results. Some patients begin to notice improvements after the first session, but the full effects typically become apparent two to four weeks after the second treatment.

Results and Longevity

What Results Can You Expect?

Profhilo delivers a natural-looking improvement in skin quality that is often described as a healthy radiant glow. Specific improvements include increased skin firmness and tightness, improved hydration levels, reduction in fine lines and crepiness, enhanced skin luminosity, and better overall skin texture. The results are subtle yet significant, meaning your skin looks healthier and more youthful without appearing artificially enhanced.

How Long Do Results Last?

Results from a full course of Profhilo typically last six to twelve months, depending on individual factors such as age, skin condition, lifestyle, and environmental exposure. Most patients choose to have a maintenance treatment every six months to sustain their results.

Profhilo vs Other Injectable Treatments

Profhilo vs Dermal Fillers

While both Profhilo and dermal fillers contain hyaluronic acid, they serve fundamentally different purposes. Dermal fillers add volume to specific areas and are used to restore lost facial volume, enhance features, or fill deep lines. Profhilo by contrast improves overall skin quality without adding volume. Many patients benefit from combining both treatments. Our experienced practitioners can advise on the best combination approach for your needs.

Profhilo vs Skin Boosters

Skin boosters such as Juvederm Volite or Restylane Vital also aim to improve skin hydration and quality. However, they use cross-linked hyaluronic acid and require multiple injection points across the treatment area. Profhilo’s unique formulation means it spreads more effectively from fewer injection points and stimulates a broader biological response.

Safety and Side Effects

Profhilo has an excellent safety profile which is one of the reasons it has become so widely adopted. Common side effects are mild and temporary, typically including small bumps at injection sites that resolve within 24 to 48 hours, mild redness or swelling, occasional minor bruising, and slight tenderness at injection points. Contraindications include pregnancy and breastfeeding, active skin infections, known allergy to hyaluronic acid, and autoimmune conditions affecting the skin.

Aftercare and Recovery

One of the advantages of Profhilo is the minimal downtime involved. Most patients return to their normal activities immediately after treatment. For the first 24 hours we recommend avoiding touching or applying pressure to the treated area, refraining from intense exercise, avoiding hot environments such as saunas, and staying well hydrated. For current pricing information please visit our pricing page or contact our team directly.

Frequently Asked Questions

Is Profhilo painful?

Most patients describe Profhilo injections as mildly uncomfortable rather than painful. The BAP technique uses only five injection points per side of the face minimising discomfort. The treatment takes approximately 15 to 20 minutes and any stinging sensation subsides quickly.

How soon will I see results?

Some patients notice improved hydration within the first week. However the full bio-remodelling effects develop gradually over the weeks following your second treatment session with optimal results visible approximately four to eight weeks after completing the two-session protocol.

Can Profhilo be combined with other treatments?

Yes, Profhilo combines beautifully with many other treatments including Botox, dermal fillers, chemical peels, and microneedling. Your practitioner will advise on appropriate timing between different treatments to ensure optimal results and safety.

How many sessions do I need?

The standard Profhilo protocol consists of two sessions four weeks apart. Following this a single maintenance session every six months is typically recommended to sustain results.

Book Your Profhilo Consultation

If you are considering Profhilo and want to discover whether it is the right treatment for your skin concerns, we invite you to book a consultation at Axiom Aesthetics. Contact our friendly team today via our contact page to take the first step towards transformed skin quality.