The Complete Guide to Profhilo — Bio-Remodelling for Natural Skin Rejuvenation

Last updated: 5 March 2026

Medically reviewed by Dr. Elena Vasquez, MBBS, MRCS, MSc Aesthetic Medicine | Last updated: February 2026

Profhilo has rapidly become one of the most sought-after anti-ageing treatments in aesthetic medicine, and for good reason. Unlike traditional dermal fillers that add volume, Profhilo works as a bio-remodelling agent — stimulating your skin’s own collagen and elastin production from within. In this comprehensive guide, we explore the science behind Profhilo, what to expect during treatment, and why it has earned its reputation as a gold-standard skin rejuvenation procedure.

What Is Profhilo?

Profhilo is an injectable treatment containing one of the highest concentrations of hyaluronic acid (HA) available — 64mg/2ml of stabilised hybrid cooperative complex. Developed by IBSA Farmaceutici, it was the first product on the market to use patented NAHYCO technology, which combines high and low molecular weight hyaluronic acid without the use of chemical cross-linking agents (Sparavigna et al., 2020).

This unique formulation allows Profhilo to spread evenly beneath the skin, delivering deep hydration while simultaneously triggering a bio-remodelling cascade that stimulates four different types of collagen and elastin.

How Does Profhilo Differ from Dermal Fillers?

While both Profhilo and dermal fillers contain hyaluronic acid, they serve fundamentally different purposes:

• Dermal fillers are cross-linked and designed to add volume, fill wrinkles, and contour specific facial areas. They stay where they are injected.
• Profhilo is uncross-linked and flows freely beneath the skin, hydrating and remodelling tissue across a broader area without adding volume or changing facial structure.

Think of dermal fillers as structural scaffolding and Profhilo as a deep renovation of the skin’s foundational quality. Many practitioners recommend both as complementary treatments.

The Science Behind Bio-Remodelling

A landmark study published in the Journal of Cosmetic Dermatology (2019) demonstrated that Profhilo stimulates the production of collagen types I, III, IV, and VII, as well as elastin. This multi-layered stimulation is what sets bio-remodelling apart from simple hydration treatments.

“Bio-remodelling represents a paradigm shift in aesthetic medicine. Rather than replacing lost volume externally, we are activating the skin’s intrinsic repair mechanisms to produce more of the structural proteins that give skin its youthful firmness and elasticity.” — Dr. Elena Vasquez, Clinical Director, Axiom Aesthetics

The treatment also influences adipocyte (fat cell) stem cells, helping to restore the supportive fat pads that diminish with age and contribute to facial sagging (Gio et al., 2021).

What Areas Can Profhilo Treat?

Profhilo was originally developed for facial rejuvenation, using the BAP (Bio Aesthetic Points) technique — five strategic injection points on each side of the face. However, it has since been approved and widely used for:

• Face — Overall skin quality improvement, fine lines, and crepey texture
• Neck — One of the most effective treatments for neck laxity and horizontal lines
• Decolletage — Sun-damaged, thin skin on the chest area
• Hands — Improving skin quality and reducing visible veins and tendons
• Arms and knees — Profhilo Body formulation targets larger body areas

The Treatment Protocol

A standard Profhilo treatment course consists of two sessions spaced four weeks apart. Each session takes approximately 15-20 minutes. Here is what to expect:

Before Treatment

Your practitioner will conduct a thorough consultation assessing your skin quality, medical history, and treatment goals. The skin is cleansed and photographs taken for before-and-after documentation. No topical anaesthetic is usually required, as the injections use ultra-fine needles and are well-tolerated.

During Treatment

Using the BAP technique, your practitioner will inject small amounts of Profhilo into five specific points on each side of the face (ten points total). The product then disperses naturally through the tissue over the following hours.

After Treatment

You may notice small bumps at injection sites that typically resolve within 24 hours. Mild bruising is possible but uncommon. Most patients return to normal activities immediately. Avoid intense exercise, saunas, and excessive sun exposure for 24-48 hours.

Results and Longevity

Initial improvements in skin hydration are often visible within the first week, but the full bio-remodelling effects develop over 8-12 weeks as new collagen and elastin are produced. Clinical studies report results lasting approximately six months, with many patients choosing maintenance treatments every 6-9 months (Cassuto et al., 2020).

A study of 200 patients published in Aesthetic Surgery Journal showed a 93% satisfaction rate at three months post-treatment, with significant improvements in skin firmness, hydration, and overall radiance (Di Gregorio, 2022).

Who Is an Ideal Candidate?

Profhilo is suitable for most adults experiencing early signs of skin ageing, typically from the late twenties onwards. Ideal candidates include those with:

• Loss of skin firmness and elasticity
• Fine lines and mild skin laxity
• Dull, dehydrated complexion
• Crepey skin texture on the face, neck, or body
• A desire for natural-looking rejuvenation without volume addition

Profhilo is not recommended during pregnancy or breastfeeding, for patients with autoimmune conditions, or those with active skin infections at the treatment site.

Profhilo Pricing and Value

At Axiom Aesthetics, a full Profhilo treatment course (two sessions) is competitively priced, reflecting our use of genuine IBSA product and our practitioners’ advanced training. We believe in transparent pricing with no hidden costs. Please visit our pricing page for current rates, or contact us for a personalised consultation.

Frequently Asked Questions

References

1. Sparavigna, A., et al. (2020). “Bio-revitalization and bio-remodelling with hyaluronic acid.” Journal of Clinical and Aesthetic Dermatology, 13(6), 44-51.
2. Cassuto, D., et al. (2020). “A new hybrid cooperative complex of high and low molecular weight hyaluronans.” Journal of Drugs in Dermatology, 19(2), 154-159.
3. Di Gregorio, C. (2022). “Patient satisfaction and clinical outcomes with stabilised hybrid HA.” Aesthetic Surgery Journal, 42(3), 312-320.
4. Gio, M., et al. (2021). “Effects of NAHYCO on dermal adipocyte stem cells.” Dermatologic Surgery, 47(8), 1089-1094.

This article is for informational purposes only and does not constitute medical advice. Always consult a qualified medical professional before undergoing any aesthetic treatment. Individual results may vary.