Skin Boosters Explained — Profhilo, Seventy Hyal, and Volite

Last updated: 5 March 2026

Skin boosters have revolutionised the approach to skin quality in aesthetic medicine. Unlike traditional dermal fillers that add volume and contour, skin boosters work beneath the surface to improve hydration, elasticity, luminosity, and overall skin health from the inside out. Products like Profhilo, Seventy Hyal, and Volite represent different approaches to the same goal — fundamentally better skin quality.

At Axiom Aesthetics, skin booster treatments are among our most popular and consistently satisfying procedures. This guide compares the leading products, explains how they work, and helps you choose the right option for your skin.

What Are Skin Boosters?

Skin boosters are injectable treatments designed to improve skin quality rather than add volume. They deliver hydrating and biostimulatory substances directly into the dermis, where they:

• Attract and retain water for deep hydration
• Stimulate fibroblasts to produce new collagen and elastin
• Improve skin elasticity and firmness
• Enhance skin luminosity and radiance
• Reduce fine lines and crepey texture

Product Comparison

Product	Active Ingredient	Concentration	Mechanism	Sessions	Results Last	Cost (£)
Profhilo	Hybrid HA (high + low MW)	64mg/2ml	Bio-remodelling: stimulates collagen I, III, IV, VII + elastin	2 (4 weeks apart)	6–9 months	£300–£450/session
Seventy Hyal 2000	Non-crosslinked HA	40mg/2ml	Hydration + mild biostimulation	3 (2–4 weeks apart)	4–6 months	£200–£350/session
Juvéderm Volite	Crosslinked HA (Vycross)	12mg/ml	Long-lasting hydration in dermis	1 (repeat at 6–9 months)	6–9 months	£300–£450/session
Restylane Skinboosters	Stabilised HA (NASHA)	20mg/ml	Dermal hydration + skin smoothing	3 (2–4 weeks apart)	6–9 months	£250–£400/session
Teosyal Redensity 1	Non-crosslinked HA + amino acids + vitamins + minerals	15mg/ml + nutrients	Hydration + nutritional support for skin cells	3–4 (2–4 weeks apart)	4–6 months	£200–£350/session

Profhilo: The Market Leader

Profhilo remains the most popular and best-studied skin booster. Its unique formulation contains the highest concentration of HA on the market (64mg per 2ml syringe) in a patented hybrid complex of high molecular weight (H-HA) and low molecular weight (L-HA) hyaluronic acid.

How Profhilo Differs From Other Skin Boosters

• Highest HA concentration: 32mg/ml vs 12–20mg/ml for other products
• Hybrid complex: H-HA provides structural support and slow release; L-HA stimulates cellular activity and has higher bioavailability
• Proven biostimulation: Clinical data shows it stimulates four types of collagen (I, III, IV, VII), elastin, and increases aquaporin-3 (water channel proteins) by 181%
• BAP injection technique: Only 5 injection points per side of the face (10 total), reducing treatment time and discomfort
• Spreads through tissue: The high concentration and specific rheology allow it to flow and integrate throughout the dermis from relatively few injection points

Profhilo Clinical Evidence

• Collagen I increased by 110% at 28 days post-injection
• Collagen III increased by 60%
• Elastin production increased by 130%
• Aquaporin-3 increased by 181%
• Patient satisfaction rates >90% in published studies
• Significant improvement in skin laxity scores on the face, neck, and hands

Seventy Hyal 2000: The Accessible Option

Seventy Hyal 2000 has gained significant popularity as a more affordable entry point to skin booster treatments. It contains 40mg of non-crosslinked hyaluronic acid with a molecular weight of 2000 kDa — optimised for skin hydration and mild biostimulation.

Key differences from Profhilo:

• Lower HA concentration (20mg/ml vs 32mg/ml)
• Non-crosslinked single molecular weight HA (vs hybrid complex)
• Requires 3 sessions vs 2 for Profhilo
• Less published clinical evidence than Profhilo
• More affordable per session (good for younger patients or first-time treatment)

Treatment Areas

Skin boosters can be used across multiple areas:

• Face: The most common area. Improves overall radiance, reduces fine lines, and combats dehydration
• Neck: Particularly effective for crepey neck skin and horizontal necklace lines
• Décolletage: Addresses sun damage, crepiness, and loss of skin quality on the chest
• Hands: Reduces crepey skin, improves volume loss appearance, and enhances skin quality on the backs of the hands
• Under-eyes: Gentle skin booster treatment can improve skin quality in the periorbital area (requires experienced practitioner)

Who Is an Ideal Candidate?

• Age 25–35: Skin boosters provide preventative hydration and early collagen stimulation. Seventy Hyal or Restylane Skinboosters are often ideal at this stage
• Age 35–50: Profhilo or Volite address developing loss of elasticity, fine lines, and dullness
• Age 50+: Profhilo combined with other biostimulatory treatments addresses more significant skin quality decline
• Any age with dehydrated, dull, or tired-looking skin: Skin boosters can make a significant difference regardless of age

What to Expect

During Treatment

• Treatment takes 15–30 minutes depending on the product and area
• Profhilo uses 10 injection points (BAP technique) — quick with minimal discomfort
• Other skin boosters may use multiple micro-injections across the treatment area
• Mild stinging at injection points; products do not contain lidocaine (unlike fillers), but discomfort is brief

After Treatment

• Small bumps (wheals) at injection points — these flatten within 24–48 hours
• Mild redness for 2–6 hours
• Avoid makeup for 12 hours; avoid exercise, alcohol, and hot environments for 24 hours
• Results develop gradually over 2–4 weeks as biostimulation takes effect
• Full results visible after the complete treatment course

Frequently Asked Questions