Profhilo vs Dermal Fillers — Which Skin Rejuvenation Treatment is Right for You?

Last updated: 5 March 2026

Two of the most popular injectable treatments available in the UK today are Profhilo and dermal fillers — yet they serve fundamentally different purposes. Understanding the distinction between these treatments is crucial for choosing the right approach to skin rejuvenation and achieving results that align with your aesthetic goals.

At Axiom Aesthetics, we offer both Profhilo and a comprehensive range of dermal fillers. In this detailed comparison, our clinical team explains how each treatment works, who they are best suited for, and how to decide which option — or combination — is right for you.

What Is Profhilo?

Profhilo is an injectable skin remodelling treatment that has revolutionised the aesthetics industry since its introduction to the UK market. Unlike traditional dermal fillers, Profhilo is not designed to add volume or change the shape of your features. Instead, it works as a bio-remodelling agent, improving skin quality from within.

Profhilo contains one of the highest concentrations of hyaluronic acid (HA) available in an injectable product — 64mg in each 2ml syringe. This ultra-pure HA is delivered using a patented technology that combines both high and low molecular weight hyaluronic acid (known as NAHYCO technology), which enables it to:

• Deeply hydrate the skin from within
• Stimulate the production of collagen and elastin
• Improve skin tone, texture, and luminosity
• Restore skin laxity without adding volume
• Create an overall healthier, more youthful skin quality

What Are Dermal Fillers?

Dermal fillers are injectable gels — most commonly based on hyaluronic acid — designed to add volume, contour facial features, and smooth lines and wrinkles. They come in varying consistencies, from soft and fluid formulations for delicate areas like the lips and tear troughs, to firm, structured gels for areas requiring significant projection such as the cheeks and jawline.

For a comprehensive overview of dermal fillers, including types, treatment areas, and recovery, see our complete guide to dermal fillers.

Key Differences at a Glance

Understanding how these treatments differ is essential for making the right choice:

• Purpose: Profhilo improves skin quality and hydration; fillers add volume and reshape features
• Mechanism: Profhilo stimulates collagen and elastin production; fillers physically occupy space beneath the skin
• Injection technique: Profhilo uses 5 specific BAP (Bio Aesthetic Points) on each side of the face; fillers are placed precisely in targeted areas
• Number of sessions: Profhilo typically requires 2 sessions 4 weeks apart; fillers are usually completed in a single session
• Results timeline: Profhilo results develop gradually over 4-8 weeks; filler results are immediate
• Longevity: Profhilo lasts approximately 6 months; fillers last 6-18 months depending on the area
• Reversibility: Both can be dissolved with hyaluronidase, though Profhilo naturally disperses more readily

Who Is Profhilo Best Suited For?

Profhilo is an excellent choice for patients who:

• Notice their skin looking dull, tired, or dehydrated despite a good skincare routine
• Are experiencing early signs of skin laxity (particularly in the lower face and neck)
• Want to improve overall skin quality without changing their facial features
• Prefer a subtle, natural enhancement that does not look obviously treated
• Are in their 30s-60s and looking for a preventative or rejuvenating treatment
• Want to complement other treatments such as anti-wrinkle injections or chemical peels

Profhilo is particularly effective on the face, neck, and hands — areas where skin quality tends to deteriorate with age but where traditional fillers may not be appropriate.

Who Are Dermal Fillers Best Suited For?

Dermal fillers are the preferred option for patients who:

• Want to add volume to specific areas (lips, cheeks, chin, jawline)
• Have deep lines or folds that need to be smoothed (nasolabial folds, marionette lines)
• Wish to enhance or reshape facial features
• Want to correct asymmetry
• Are looking for immediate, visible results
• Have specific volume loss due to ageing that needs targeted restoration

The Treatment Experience Compared

Profhilo Treatment

A Profhilo session at Axiom Aesthetics follows a precise protocol:

• The skin is cleansed and the 5 BAP injection points are identified on each side of the face
• Small boluses of Profhilo are injected just beneath the skin at each point
• The entire process takes approximately 15-20 minutes
• You will notice small bumps at the injection sites which typically flatten within 24-48 hours
• A second session is performed 4 weeks later to complete the treatment course

Dermal Filler Treatment

A filler appointment is more tailored to the individual:

• Treatment areas are assessed and a personalised plan is created
• Numbing cream may be applied 15-20 minutes before injection
• Filler is injected using a needle or cannula, with precise placement and moulding
• Treatment time varies from 15-45 minutes depending on the number of areas
• Results are visible immediately, with final results at 2-4 weeks once swelling settles

Combining Profhilo and Dermal Fillers

One of the most frequently asked questions at our clinic is whether Profhilo and dermal fillers can be combined. The answer is a resounding yes — in fact, this combination often produces the most comprehensive rejuvenation results.

We often describe Profhilo as the foundation and fillers as the architecture. Profhilo creates a canvas of healthy, hydrated, luminous skin, while fillers provide the structural enhancement and volume restoration. Together, they deliver results that neither treatment could achieve alone. — Axiom Aesthetics Clinical Team

When combining treatments, we typically recommend completing the Profhilo course first, then adding fillers 2-4 weeks after the second Profhilo session. This allows the skin to benefit fully from the bio-remodelling effects before volume is added.

Cost Comparison

Understanding the investment required for each treatment helps in making an informed decision:

• Profhilo (full course of 2 sessions): £500-£700
• Dermal fillers (per syringe): £250-£600 depending on area and product
• Combination treatment: From £750-£1,200

When considering cost, factor in the longevity of results and the frequency of maintenance treatments. Profhilo is typically repeated every 6 months, while filler top-ups may be needed every 9-18 months depending on the area treated.

Safety and Side Effects

Both treatments have excellent safety profiles when performed by qualified practitioners:

Profhilo side effects are generally very mild: small bumps at injection sites (resolve in 24-48 hours), mild redness, and occasional bruising. Serious complications are exceptionally rare.

Dermal filler side effects include swelling, bruising, redness, and tenderness, all of which are temporary. More significant risks such as vascular occlusion are rare but can be managed by experienced practitioners. See our article on post-treatment care for detailed aftercare guidance.

Frequently Asked Questions

Can Profhilo replace my dermal fillers?

Profhilo is not a replacement for dermal fillers — they serve different purposes. If you need volume restoration (fuller lips, more defined cheeks, or a stronger jawline), Profhilo alone will not achieve this. However, if your primary concern is skin quality — dullness, fine lines, crepey texture, or mild laxity — Profhilo may be all you need.

Which treatment hurts more?

Both treatments involve injections, so some discomfort is expected. Profhilo injections tend to cause a brief stinging sensation, while dermal fillers (which often contain lidocaine) may cause more of a pressure feeling. Most patients tolerate both treatments very well, rating discomfort at 2-4 out of 10.

How soon will I see results from Profhilo?

Unlike fillers, which show immediate results, Profhilo results develop gradually. You may notice improved hydration within the first week, but the full bio-remodelling effects — including improved skin texture, tone, and firmness — become apparent 4-8 weeks after your second session.

At what age should I start considering Profhilo?

There is no fixed age, but most patients who benefit from Profhilo are in their 30s and above. Patients in their 30s often use it as a preventative measure to maintain skin quality, while those in their 40s-60s typically see the most dramatic improvements in hydration and laxity. Our practitioners will advise on timing during your consultation.

Can Profhilo be used on the body?

Yes. While the face is the most common treatment area, Profhilo can also be used on the neck, decolletage, hands, arms, knees, and abdomen. These areas often show signs of ageing but are not suitable for traditional fillers. Profhilo Body, a specific formulation, is also available for larger treatment areas.

---

Medical Disclaimer: This article is provided for informational purposes only and does not constitute medical advice. Every patient is unique, and treatment outcomes may vary. A thorough consultation with a qualified aesthetic practitioner is essential before undergoing any procedure. All treatments at Axiom Aesthetics are performed by trained, insured professionals in our CQC-aware clinical environment in London.

Last reviewed: February 2026 | Axiom Aesthetics, London