Polynucleotides — The Next Generation of Skin Regeneration

Last updated: 5 March 2026

Polynucleotides (PNs) represent one of the most exciting developments in regenerative aesthetics. Derived from salmon DNA, these biocompatible molecules work at a cellular level to repair, regenerate, and rejuvenate ageing skin.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides — the building blocks of DNA. When injected into the skin, they stimulate fibroblast activity, promoting collagen and elastin production while reducing inflammation.

How They Differ from Skin Boosters

While skin boosters primarily hydrate via hyaluronic acid, polynucleotides actively regenerate tissue. They improve skin quality from a biological level, making them particularly effective for:

• Thin, crepey skin around the eyes
• Neck and décolletage rejuvenation
• Acne scarring and textural irregularities
• Dark under-eye circles (tear trough)
• Overall skin quality improvement

Treatment Protocol

A typical course consists of three to four treatments spaced three to four weeks apart. Results build progressively, with optimal improvement visible around eight to twelve weeks after the final session.

Safety Profile

Polynucleotides have an excellent safety profile due to their biocompatibility. The most common side effects are mild swelling and bruising at injection sites, typically resolving within 48 hours.

Who Is a Good Candidate?

Anyone seeking to improve skin quality, particularly those with signs of ageing, sun damage, or scarring. PNs are suitable for all skin types and tones.

Interested in polynucleotide therapy? Schedule your assessment at our Harley Street clinic.

Individual results may vary. Always consult a qualified medical professional.