TL;DR
Platelet-Rich Fibrin (PRF) represents the next evolution in regenerative aesthetics, building upon the established foundation of PRP (Platelet-Rich Plasma) therapy. By utilising a simplified preparation method that produces a fibrin...
Last updated: 5 March 2026
Platelet-Rich Fibrin (PRF) represents the next evolution in regenerative aesthetics, building upon the established foundation of PRP (Platelet-Rich Plasma) therapy. By utilising a simplified preparation method that produces a fibrin matrix rich in growth factors, cytokines, and white blood cells, PRF offers sustained release of healing signals over 7–14 days compared to PRP’s rapid release over hours. This guide explores the science, applications, and evidence behind this exciting development.
At Axiom Aesthetics, we stay at the forefront of regenerative aesthetic treatments. This guide explains how PRF differs from traditional PRP, what the evidence shows, and who might benefit from this treatment.
PRP vs PRF: Understanding the Difference
| Feature | PRP (Platelet-Rich Plasma) | PRF (Platelet-Rich Fibrin) |
|---|---|---|
| Preparation | Centrifuged with anticoagulant; separated plasma layer collected | Centrifuged without anticoagulant; natural clotting produces fibrin matrix |
| Additives | Contains anticoagulant (citrate, heparin) | No additives — 100% autologous |
| Growth factor release | Rapid burst release (hours) | Sustained release over 7–14 days via fibrin matrix |
| White blood cells | Varies (may be depleted in some kits) | Concentrated — provides additional growth factors and immune signalling |
| Fibrin scaffold | No | Yes — provides a structural matrix for cellular interaction |
| Injectable form | Liquid | i-PRF: liquid injectable; A-PRF: membrane (for surgical use) |
| Cost per session | £250–£400 | £300–£500 |
The Science Behind PRF
PRF was originally developed by Dr. Joseph Choukroun for dental and oral surgery applications. The key innovation is the elimination of anticoagulants during blood processing, allowing natural fibrin formation to occur. This creates a three-dimensional fibrin scaffold that:
- Traps platelets, leukocytes, and growth factors within its matrix
- Releases these growth factors gradually over 7–14 days (compared to the rapid burst release of PRP)
- Provides a physical scaffold that may support tissue regeneration
- Contains higher concentrations of white blood cells, which secrete additional growth factors including VEGF, TGF-β, and PDGF
Key Growth Factors in PRF
- PDGF (Platelet-Derived Growth Factor): Stimulates fibroblast proliferation and collagen production
- TGF-β (Transforming Growth Factor Beta): Promotes extracellular matrix synthesis and tissue remodelling
- VEGF (Vascular Endothelial Growth Factor): Stimulates new blood vessel formation (angiogenesis)
- EGF (Epidermal Growth Factor): Promotes epithelial cell growth and wound healing
- IGF-1 (Insulin-like Growth Factor): Stimulates cell growth and differentiation
PRF Applications in Aesthetic Medicine
1. Facial Rejuvenation
Injectable PRF (i-PRF) can be injected into the dermis for overall skin quality improvement, targeting fine lines, dull skin, and loss of elasticity. The sustained growth factor release promotes gradual, natural improvement.
2. Under-Eye Rejuvenation
PRF is particularly valuable for the delicate under-eye area, where many practitioners prefer it over fillers for mild-to-moderate dark circles and hollowing. The growth factors improve skin thickness and reduce the vascular congestion contributing to dark circles.
3. Hair Restoration
PRF injected into the scalp stimulates hair follicle stem cells, extends the anagen (growth) phase, and improves hair density. Early comparative studies suggest PRF may be more effective than PRP for androgenetic alopecia due to sustained growth factor release.
4. Post-Procedure Enhancement
PRF applied after microneedling or laser treatment provides a concentrated source of growth factors directly to the treated skin, potentially accelerating healing and enhancing collagen stimulation.
Expert Insight
“The theoretical advantages of PRF over PRP — sustained growth factor release, no additives, higher leukocyte concentration — are compelling. Early clinical data supports these advantages, particularly for hair restoration and skin quality improvement. However, we are still in the early stages of building a robust clinical evidence base. We offer PRF at Axiom Aesthetics because the science is sound and the safety profile is excellent (it is your own blood), but we present it as an evolving treatment rather than a proven gold standard.”
— Clinical Team, Axiom Aesthetics
The Treatment Process
- Blood draw: 20–40ml of blood is drawn from the arm (similar to a standard blood test)
- Centrifugation: Blood is processed in a centrifuge at lower speeds than PRP (700–1000 RPM) for shorter durations (3–8 minutes). No additives are used
- Collection: The i-PRF (liquid PRF) layer is collected — typically 2–4ml per 10ml of blood drawn
- Application: Injected into the skin using fine needles or applied topically after microneedling. Must be used within 15–20 minutes before the fibrin fully polymerises
- Duration: 45–60 minutes total (including preparation)
Evidence Summary
- Wang et al. (2020): Systematic review of PRF in regenerative medicine confirmed sustained growth factor release for 7–14 days and superior cellular response compared to PRP in vitro
- Miron et al. (2021): Demonstrated that i-PRF promotes significantly higher fibroblast migration and collagen expression than PRP in cell culture studies
- Gentile & Garcovich (2020): Randomised trial comparing PRF and PRP for androgenetic alopecia showed 17% greater improvement in hair density with PRF at 12 months
- Caution: Most studies are in vitro or small-scale clinical studies. Large randomised controlled trials specifically for aesthetic indications are still needed
Frequently Asked Questions
Is PRF better than PRP?
PRF has theoretical advantages over PRP — sustained growth factor release, no anticoagulant additives, and higher leukocyte concentration. Early clinical studies support these advantages, particularly for hair restoration. However, PRP has a much larger evidence base with decades of clinical use across many medical specialties. Both treatments are effective and safe. The choice between them may depend on the specific indication, practitioner preference, and individual patient response. We can discuss which option is most suitable during your consultation.
How many PRF sessions are needed?
For facial rejuvenation: 3 sessions, 4–6 weeks apart, with maintenance every 6–12 months. For hair restoration: 3–4 sessions, 4–6 weeks apart, with maintenance every 4–6 months. For post-procedure enhancement: single session applied immediately after the primary treatment. Results are cumulative and become more apparent after the second and third sessions as collagen remodelling progresses.
Is PRF safe?
PRF has an excellent safety profile because it is 100% autologous — derived entirely from the patient’s own blood with no additives. There is virtually no risk of allergic reaction, transmission of blood-borne disease, or foreign body reaction. The main risks are those common to any injection: bruising, swelling, and tenderness at injection sites. These are temporary and typically resolve within 3–7 days. PRF is one of the safest injectable treatments available.
Can PRF replace dermal fillers?
No. PRF improves skin quality, thickness, and texture through growth factor stimulation, but it does not provide the immediate volumising effect of dermal fillers. PRF cannot fill deep wrinkles, augment lips, or contour the jawline as fillers do. However, PRF can complement fillers by improving the skin quality around filler-treated areas. For patients who prefer completely natural treatments without synthetic products, PRF offers a biological alternative for subtle skin improvement.
What is the recovery like after PRF treatment?
Recovery after PRF injection is minimal. Expect mild swelling and bruising at injection sites for 2–5 days. Some patients report a slight aching sensation for 24–48 hours. There is no significant downtime — most patients return to normal activities immediately. Avoid vigorous exercise, hot baths, and alcohol for 24 hours. Post-procedure, the skin may have small injection marks that are easily concealed with mineral makeup after 24 hours. Contact Axiom Aesthetics to learn more about PRF treatment.
Medical Disclaimer
This article is provided for informational purposes only and does not constitute medical advice. PRF is a relatively new aesthetic treatment with a growing but still developing evidence base. Individual results vary. A consultation with a qualified medical professional is essential before treatment. Contact Axiom Aesthetics to discuss PRF therapy.
This content is provided for informational purposes only and does not constitute medical advice. Individual results may vary. Always consult with a qualified medical professional before undergoing any treatment. All treatments carry potential risks and side effects which will be fully discussed during your consultation.
Medical Disclaimer: This content is provided for informational purposes only and does not constitute medical advice. Individual results may vary. Always consult with a qualified medical professional before undergoing any treatment. All treatments carry potential risks and side effects which will be fully discussed during your consultation.